TGM2-mediated histone serotonylation is an epigenetic cardioprotective mechanism in HFpEF
Ryo Ogawara, Tomofumi Misaka, Yoshinori Suzuki, Satoshi Okochi, Shohei Ichimura, Shunsuke Miura, Tetsuro Yokokawa, Shu Taira, Satoshi Waguri, Masayoshi Oikawa, Akiomi Yoshihisa, Takafumi Ishida, Yasuchika Takeishi
This study identifies TGM2-mediated histone serotonylation as a cardioprotective epigenetic mechanism in HFpEF, showing its role in stress response and cardiac function.
bioRxiv · Jul 1, 2026 · PreprintPathology