Investigating the Impact of Hypoxia and Syncytialization on Lipid Nanoparticle-Mediated mRNA Delivery to Placental Cells
Rachel E. Young, Tara Vijayakumar, Logan J. Reilley, Krisha Darji, Diya Patel, Samuel I. Hofbauer, Mohamad‐Gabriel Alameh, Drew Weissman, Rachel Riley
This study evaluates how hypoxia affects lipid nanoparticle-mediated mRNA delivery to placental cells and shows that therapeutic mRNA can restore protein levels under hypoxic conditions.
Bioengineering & Translational Medicine · Jan 22, 2026Peer-reviewedBioengineering