Oral prodrug of a novel glutathione surrogate reverses metabolic dysregulation and attenuates neurodegenerative process in APP/PS1 mice
Swetha Pavani Rao, Aminat Omolola Imam-Fulani, Wei Xie, Samuel Phillip, Krishna Chennavajula, Erin B. Lind, Ying Zhang, Robert Vince, Michael K. Lee, Swati S. More
This paper evaluates a prodrug of a glutathione surrogate in an Alzheimer's mouse model, showing it reduces oxidative stress, amyloid pathology, and neurodegeneration while identifying metabolic biomarkers.
bioRxiv · Jan 15, 2025 · PreprintNeuroscience