Ying Zhang

This study identifies HSF1's role in regulating thalamostriatal synapses and cognitive flexibility by controlling transcriptional programs and actin dynamics.

This study shows that mutant ATXN1 affects microglia in human and mouse models, leading to cognitive, mood, and motor deficits in SCA1 mice, which are ameliorated by reducing mutant ATXN1 in microglia.

This study investigates VGF's role in nucleus accumbens synaptic and opioid-evoked plasticity, finding it modulates drug-evoked adaptations and behavior.

This study identifies CK2 as a regulator of tauopathy by modulating tau phosphorylation, neuroinflammation, and synaptic dysfunction in mice.

This paper evaluates a prodrug of a glutathione surrogate in an Alzheimer's mouse model, showing it reduces oxidative stress, amyloid pathology, and neurodegeneration while identifying metabolic biomarkers.

This study investigates how cerebellar dysfunction in SCA1 affects prefrontal cortex function and cognition, finding that cerebellar degeneration can both impair and ameliorate PFC dysfunction depending on disease context.

This study shows that reducing CK2 in HD mice improves neuroinflammation, HTT aggregation, and motor deficits by reducing synucleinopathy.

The paper identifies regional transcriptional and physiological differences in Purkinje cells of the cerebellum in SCA1 mice, showing reduced heterogeneity and increased vulnerability in the posterior cerebellum.

The paper uses single-nuclei RNA sequencing to study glial cell changes in a SCA1 mouse model, identifying non-cell autonomous gene expression alterations in astrocytes and oligodendrocytes that may contribute to disease pathogenesis.

This paper presents the genome of the zebra mussel, Dreissena polymorpha, providing insights into its invasive success and creating a resource for invasive species research.

This study presents haplotype-phased genome assemblies of two dikaryotic Puccinia coronata f. sp. avenae isolates, revealing structural variation and heterozygous SNPs, and identifies co-expressed effector candidates associated with virulence differences.