Robert Vince

Oral prodrug of a novel glutathione surrogate reverses metabolic dysregulation and attenuates neurodegenerative process in APP/PS1 mice

This paper evaluates a prodrug of a glutathione surrogate in an Alzheimer's mouse model, showing it reduces oxidative stress, amyloid pathology, and neurodegeneration while identifying metabolic biomarkers.

Modulation of endogenous opioid signaling by inhibitors of puromycin sensitive aminopeptidase

This paper develops PSA inhibitors to prolong enkephalin stability and reduce pain, showing analgesic effects in vivo and confirming their mechanism through pharmacokinetics and modeling.