Interactome Specialization Predicts Genome-Wide Binding-Site Degeneracy in Drosophila melanogaster Transcription Factors
Arun Ram Ponnambalam, Krishnan Venkiteswaran Pottore
The paper shows that Drosophila transcription factors with more specialized interaction modules have more degenerate DNA-binding motifs, while generalist TFs rely on more specific sequences.