Kristan G. Singletary

This study investigates how a Shank3 mutation affects the molecular response to sleepiness across development in mice, finding altered gene expression patterns linked to sleep issues in autism.

This study examines sleep patterns in Mecp2-/y mice, finding time-of-day-dependent sleep alterations and worsened sleep architecture after sleep deprivation.

The paper analyzes RNA-seq data from sleep-deprived and recovery sleep mice to identify gene expression changes linked to sleep homeostasis and SD effects.

The paper examines how sleep deprivation affects gene expression in the prefrontal cortex of developing mice, identifying age-dependent changes in gene categories.

This study shows that Shank3{Delta}C mice have reduced total sleep, altered REM/NREM sleep dynamics, and impaired sleep latency responses, suggesting sleep abnormalities are a core feature of ASD.

The paper shows astroglial calcium concentrations change with sleep and wake states, and mediate sleep need by affecting the homeostatic response to sleep deprivation.

This study shows that Shank3 modulates sleep and circadian transcription factor expression in mice, with sleep deprivation exacerbating gene expression differences between Shank3 mutants and wild types.