Ashley M. Ingiosi

This study investigates how a Shank3 mutation affects the molecular response to sleepiness across development in mice, finding altered gene expression patterns linked to sleep issues in autism.

The paper analyzes RNA-seq data from sleep-deprived and recovery sleep mice to identify gene expression changes linked to sleep homeostasis and SD effects.

This study shows that activating basal forebrain astrocytes increases wakefulness without increasing sleep drive, suggesting sleep regulation involves specific neuronal-glial circuits.

The paper shows astroglial calcium concentrations change with sleep and wake states, and mediate sleep need by affecting the homeostatic response to sleep deprivation.

This study shows that Shank3 modulates sleep and circadian transcription factor expression in mice, with sleep deprivation exacerbating gene expression differences between Shank3 mutants and wild types.