Escherichia coli-induced gut IL-33 release inhibits lung type 2 allergic responses
Caio Loureiro Salgado, Marina Caçador Ayupe, Juliana Falcão Rodrigues, Leonardo Mandu Gonçalves, Luísa Menezes-Silva, Bárbara Cristina Pizzolante, Bernardo de Castro Oliveira, Guilherme William da Silva, Francielly Moreira, Érick Esteves de Oliveira, Marcelo Valdemir de Araújo, Gabriele Manamy Baba Rodrigues, Jofer Andree Zamame Ramirez, Kristen Brammer, Igor Santiago-Carvalho, , Denise Morais da Fonseca
This study shows that exposure to ETEC or its toxin LT reduces lung allergic inflammation by inhibiting IL-33 responses in ILC2 cells through a gut-derived negative feedback loop.
bioRxiv · Nov 7, 2025 · PreprintImmunology