The S1 protein of SARS-CoV-2 crosses the blood-brain barrier: Kinetics, distribution, mechanisms, and influence of ApoE genotype, sex, and inflammation
Elizabeth M. Rhea, Aric Flint Logsdon, Kim M. Hansen, Lindsey M. Williams, May J. Reed, Kristen K. Baumann, Sarah J. Holden, Jacob Raber, William A. Banks, Michelle A. Erickson
This study shows that SARS-CoV-2's S1 protein crosses the murine blood-brain barrier via adsorptive transcytosis and is distributed throughout the brain and peripheral tissues.
bioRxiv · Jul 15, 2020 · PreprintNeuroscience