Jacob Raber

This study identifies epigenetic and transcriptomic changes in the hippocampus and blood of an Alzheimer's mouse model before amyloidosis onset, suggesting blood methylation as a potential biomarker.

This study investigates the protective effects of the APOE CC mutation against Aβ, tau, and α-synuclein pathologies in mouse models of neurodegenerative diseases.

This study shows that systemic exposure to SARS-CoV-2 virus-like particles disrupts cortical neuronal activity in mice, with persistent effects and heightened vulnerability in htau mice.

This study shows that mild neonatal hypoxia causes long-term hippocampal learning and memory deficits in mice through CK2-mediated dysregulation of KCNN2 channels, independent of white matter injury.

This paper introduces a method to record single-cell cortical activity from freely-moving mice using CaMPARI, revealing task-dependent activity patterns in motor and somatosensory cortices.

This study shows that antisense oligonucleotides targeting alpha-synuclein reduce Lewy body pathology and improve cognitive and motor performance in a mouse model of synucleinopathy.

This study shows that SARS-CoV-2's S1 protein crosses the murine blood-brain barrier via adsorptive transcytosis and is distributed throughout the brain and peripheral tissues.