Heparan sulfate glycosaminoglycans mediate CXCL4 (PF4) transport across the blood-brain barrier and effects on neurogenesis
Riley R. Weaver, Anna L. Gray, Saudina Mateus-Gomes, Amanda J. L. Ridley, Sean Patrick Giblin, Holly L. Birchenough, Francis C. Peterson, K. Lowe, Yui Matsubara, Iashia Z. Mulholland, Ingo Schießl, Thomas A. Jowitt, James Edward Pease, William A. Banks, Réjane Rua, , Douglas P. Dyer
This study shows CXCL4 enters the brain via GAG-binding to BBB proteoglycans and promotes neurogenesis through GAG-mediated oligomerization.
bioRxiv · Apr 23, 2025 · PreprintNeuroscience