Autosomal Allelic Inactivation: Variable Replication and Dosage Sensitivity
Michael B. Heskett, Athanasios E Vouzas, Brian Johnstone, Krister P. Freese, Phillip A. Yates, Philip F. Copenhaver, Paul T. Spellman, David M. Gilbert, Mathew J. Thayer
The paper identifies and characterizes Autosomal Inactivation/Stability Centers (I/SCs) as loci with allele-specific epigenetic regulation of replication timing and gene expression, showing dosage sensitivity and implications for human diseases.
bioRxiv · Aug 13, 2025 · PreprintGenomics