Phillip A. Yates

Autosomal Allelic Inactivation: Variable Replication and Dosage Sensitivity

The paper identifies and characterizes Autosomal Inactivation/Stability Centers (I/SCs) as loci with allele-specific epigenetic regulation of replication timing and gene expression, showing dosage sensitivity and implications for human diseases.

A high-throughput protein tagging toolkit that retains endogenous UTRs for studying gene regulation in Kinetoplastids.

The paper introduces a CRISPR/Cas9-based protein tagging system for Kinetoplastids that preserves endogenous regulatory elements and demonstrates its utility in studying gene regulation.

ASAR lncRNAs control DNA replication timing through interactions with multiple hnRNP/RNA binding proteins

The paper identifies ASAR lncRNAs as regulators of DNA replication timing through interactions with hnRNP proteins, showing their role in chromosome stability and replication synchronization.

Epigenetic Control of Hundreds of Chromosome-Associated lncRNA Genes Essential for Replication and Stability

The paper identifies hundreds of epigenetically controlled long noncoding RNA genes essential for chromosome replication and stability, validating their role in chromosomal integrity.

Distinct cis-acting elements govern purine-responsive regulation of the Leishmania donovani nucleoside transporters, LdNT1 and LdNT2

The paper identifies distinct cis-acting elements regulating purine-responsive gene expression in Leishmania donovani, specifically for LdNT1 and LdNT2.

Purine-responsive expression of the Leishmania donovani NT3 purine nucleobase transporter is mediated by a conserved RNA stem-loop

The paper identifies a conserved RNA stem-loop in the LdNT3 mRNA 3' UTR that mediates purine-responsive upregulation in Leishmania donovani, with species-specific functionality due to variant bases.