Brian Johnstone

This study shows that neuropeptides SP and CGRP influence sex-specific synovial immunity and cartilage degradation in aging mice, with their absence providing structural protection.

A granular extracellular matrix hydrogel implanted in a goat condyle provided a robust repair, filling the defect tissue with integrated, hyaline-like cartilage at 12 months.

The paper identifies and characterizes Autosomal Inactivation/Stability Centers (I/SCs) as loci with allele-specific epigenetic regulation of replication timing and gene expression, showing dosage sensitivity and implications for human diseases.