Michael B. Heskett

The paper identifies and characterizes Autosomal Inactivation/Stability Centers (I/SCs) as loci with allele-specific epigenetic regulation of replication timing and gene expression, showing dosage sensitivity and implications for human diseases.

This study develops a novel pancreatic cancer mouse model by expressing Myc and mutant Kras in adult acinar cells, showing metastasis and therapeutic resistance similar to human PDAc.

The paper identifies ASAR lncRNAs as regulators of DNA replication timing through interactions with hnRNP proteins, showing their role in chromosome stability and replication synchronization.

This study investigates the epigenetic regulation of DAX-1 in cancer cell lines, showing that methylation of CpG islands in the promoter affects DAX-1 expression.

The paper identifies hundreds of epigenetically controlled long noncoding RNA genes essential for chromosome replication and stability, validating their role in chromosomal integrity.

The paper identifies a new lncRNA gene, ASAR6-141, that regulates replication timing of human chromosome 6 through reciprocal monoallelic expression and inactivation/stability centers.