Loop extrusion creates rare, long-lived encounters underlying enhancer-promoter communication
Mattia Alberto Ubertini, Nessim Louafi, Kristina Landry, Pavel I. Kos, Grégory Roth, Edoardo Marchi, Julie Cramard, Guido Tiana, Luca Giorgetti
The paper identifies rare, long-lived chromatin encounters driven by cohesin-mediated loop extrusion as key to enhancer-promoter communication and shows they explain transcriptional dynamics.
bioRxiv · Sep 24, 2025 · PreprintMolecular Biology