Julie Cramard

This study shows that enhancer position within a cis-regulatory landscape modulates transcriptional burst frequency and uniformity in single cells.

The paper identifies rare, long-lived chromatin encounters driven by cohesin-mediated loop extrusion as key to enhancer-promoter communication and shows they explain transcriptional dynamics.

The paper quantifies how enhancer-promoter interactions influence transcription through nonlinear relationships and reveals mechanisms of transcriptional control via chromosome structure.

The paper uses live-cell imaging to show that chromosomal contacts within TADs are dynamic and stabilized by CTCF and cohesin.

This study compares NuRD's role in human and mouse pluripotent stem cells, finding that NuRD is required for transcriptional responses to differentiation signals in both, but with distinct functional differences between species.

The paper shows that MTA proteins in ES cell NuRD complex are functionally redundant, and NuRD is essential for maintaining differentiation trajectory during early lineage commitment.