Author

Nessim Louafi

Friedrich Miescher InstituteORCID 0009-0005-0417-3034Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Approach:simulation· 1 Approach:statistical model· 1

Frequent Co-Authors

Luca GiorgettiiD· 2 shared David WeniD· 1 shared Edoardo MarchiiD· 1 shared Elphège Pierre NoraiD· 1 shared Erika C. AndersoniD· 1 shared Geoffrey FudenbergiD· 1 shared Grégory RothiD· 1 shared Guido TianaiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersMolecular Biology

Luca GiorgettiORCID

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2 papers

Recent·Most cited

Molecular BiologybioRxivPreprintSep 24, 2025

Loop extrusion creates rare, long-lived encounters underlying enhancer-promoter communication

Mattia Alberto Ubertini, Nessim Louafi, Kristina Landry…·Luca Giorgetti

The paper identifies rare, long-lived chromatin encounters driven by cohesin-mediated loop extrusion as key to enhancer-promoter communication and shows they explain transcriptional dynamics.

8 citations

statistical modelsimulation

𝕏 PostBluesky

Molecular BiologybioRxivPreprintAug 14, 2025

Dosage sensitivity of the loop extrusion rate confers tunability to genome folding while creating vulnerability to genetic disruption

Rini Shah, Maxime M. C. Tortora, Nessim Louafi…·Elphège Pierre Nora

The paper shows that the extrusion rate of cohesin is tunable by cofactor dosage and buffers chromosome structure against genetic disruption.

15 citations

experimental assay

𝕏 PostBluesky