Grégory Roth

This study shows that enhancer position within a cis-regulatory landscape modulates transcriptional burst frequency and uniformity in single cells.

The paper introduces OCW, an automated segmentation pipeline for C. elegans embryos, and BAAM for single-cell quantitation, revealing distinct cell populations with varying transcriptional burst frequencies.

The paper identifies rare, long-lived chromatin encounters driven by cohesin-mediated loop extrusion as key to enhancer-promoter communication and shows they explain transcriptional dynamics.

The paper systematically mutagenizes human bZIP domains and uses deep mutational scanning to quantify interactions, revealing complex genetic architecture and enabling synthetic bZIP design.

This study investigates how reproductive mode affects ecological diversification by comparing sexual and asexual lineages, finding that sexual reproduction promotes faster niche occupancy and higher diversity.

The paper quantifies how enhancer-promoter interactions influence transcription through nonlinear relationships and reveals mechanisms of transcriptional control via chromosome structure.

The paper uses live-cell imaging to show that chromosomal contacts within TADs are dynamic and stabilized by CTCF and cohesin.

This study uses single-molecule imaging to show that translating mRNAs decay faster than non-translating ones, with miRNAs mediating efficient degradation of both.

The paper introduces a phase-gated and unidirectional coupling mechanism to explain cell synchronization in the presomitic mesoderm through Notch signaling.

The paper shows that uncoordinated BER activity at DNA lesions causes DSB accumulation in yeast exposed to Zeocin, leading to genomic fragmentation.

The paper uses single-molecule imaging to study mRNA localization in stress granules and processing bodies during the integrated stress response and finds similar translation and degradation rates for mRNA in these compartments compared to cytosol.