Author

Kristof Tigyi

Howard Hughes Medical Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 2 Evolutionary Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Assay:whole-genome sequencing· 3 Approach:experimental assay· 2 Research Focus:genome assembly· 2 Approach:statistical model· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:database / resource· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

Benedict PateniD· 4 shared Adam M. PhillippyiD· 3 shared Evan E. EichleriD· 3 shared Karen H. MigaiD· 3 shared Mitchell Robert VollgeriD· 3 shared Sergey KoreniD· 3 shared Alice YoungiD· 2 shared Andrey V. BzikadzeiD· 2 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersBioinformatics

Benedict PatenORCID

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Author profile →

4 papers

Recent·Most cited

Complete genomic and epigenetic maps of human centromeres

Nicolas Altemose, Glennis A. Logsdon, Andrey V. Bzikadze, Pragya Sidhwani, Sasha A. Langley, Gina Viviana Caldas, Savannah J. Hoyt, Lev I. Uralsky, Fedor Ryabov, Colin J. Shew, Michael E.G. Sauria, Matthew Borchers, Ariel Gershman, Alla Mikheenko, Valery A. Shepelev, , Karen H. Miga

The paper presents a comprehensive analysis of fully assembled human centromeres, revealing their architecture, variation, and evolutionary dynamics at high resolution.

Science · Mar 31, 2022Peer-reviewedGenomics

Telomere-to-telomere assembly of a complete human X chromosome

Karen H. Miga, Sergey Koren, Arang Rhie, Mitchell Robert Vollger, Ariel Gershman, Andrey V. Bzikadze, Shelise Y. Brooks, Edmund Howe, David Porubskỳ, Glennis A. Logsdon, Valérie Schneider, Tamara Potapova, Jonathan M. D. Wood, William Chow, Joel C. Armstrong, , Adam M. Phillippy

The paper presents a gapless, telomere-to-telomere assembly of the human X chromosome using ultra-long-read nanopore sequencing and complementary technologies.

Nature · Jul 14, 2020Peer-reviewedBioinformatics

Efficient de novo assembly of eleven human genomes using PromethION sequencing and a novel nanopore toolkit

Kishwar Shafin, Trevor Pesout, Ryan Lorig-Roach, Marina Haukness, Hugh E. Olsen, Colleen M. Bosworth, Joel C. Armstrong, Kristof Tigyi, Nicholas W. Maurer, Sergey Koren, Fritz Joachim Sedlazeck, Tobias Marschall, Simon Mayes, Vânia Costa, Justin M. Zook, , Benedict Paten

The paper presents an optimized PromethION nanopore sequencing method and new computational tools for efficient human genome assembly, achieving high accuracy and speed.

Nature Biotechnology · May 4, 2020Peer-reviewedBioinformatics

KRAB Zinc Finger Proteins coordinate across evolutionary time scales to battle retroelements

Jason D Fernandes, Maximilian Haeussler, Joel Armstrong, Kristof Tigyi, Joshua Gu, Natalie Filippi, Jessica Pierce, Tiffany Thisner, Paola Angulo, Sol Katzman, Benedict Paten, David Haussler, Sofie R Salama

The paper examines the evolutionary arms race between KRAB Zinc Finger Proteins (KZNFs) and retrotransposable elements (RTEs), showing how KZNFs adapt to suppress RTEs over time.

bioRxiv · Sep 27, 2018 · PreprintEvolutionary Biology