Michael E.G. Sauria

The paper analyzes the genomic diversity of C. tropicalis, finding geographic correlation and hyper-divergent regions linked to environmental adaptation.

NemaSize is an AI pipeline that accurately measures nematode body size across complex postures, outperforming CellProfiler in curved and overlapping animals.

This study shows that a male-expressed mating plug in nematodes increases female fertility by extending reproductive windows and reducing sperm loss, indicating reproductive cooperation rather than male competition.

The paper analyzes over 2,000 Caenorhabditis briggsae wild strains to uncover genetic diversity, population structure, and evolutionary mechanisms shaping phenotypic variation.

This study identifies conserved and species-specific cis-regulatory elements in human and mouse blood cells using integrative epigenomic analysis and clustering.

The paper presents the complete sequence of a human Y chromosome, correcting errors in the GRCh38 reference and adding over 30 million base pairs.

The paper uses a complete human genome assembly to analyze epigenetic patterns in previously uncharacterized genomic regions, revealing methylation and chromatin accessibility features in satellite DNA and centromeres.

The paper presents a comprehensive analysis of fully assembled human centromeres, revealing their architecture, variation, and evolutionary dynamics at high resolution.

The T2T-CHM13 reference genome improves read mapping and variant calling across diverse samples, reducing false positives and enabling novel variant discovery.

The paper investigates the spatiotemporal development of M and L cones in the human retina, finding that retinoic acid signaling promotes M cone fate early in development.

The paper integrates epigenomic and transcriptomic data from mouse hematopoiesis to identify regulatory elements and their dynamics across cell types.

The paper evaluates reproducibility and quality measures for Hi-C data using real and simulated datasets, showing that specialized methods outperform simple correlation analysis.

The paper identifies TADs as button loci that facilitate homologous chromosome pairing and cell-type-specific interchromosomal gene regulation in Drosophila.

This study shows that lamins maintain TAD-TAD interactions and regulate chromatin domain interactions, which are correlated with transcription changes in mouse ES cells.

QuASAR assesses Hi-C data quality by detecting noise, estimating sequencing returns, and measuring replicate agreement across resolutions.

This study uses chromosome conformation paints to show that LADs form compact regions at the nuclear lamina and are linked to B compartments, with some regions interacting with the A compartment.