Seed-Guided De Novo Design Expands the Structural Diversity of Antitoxin Protein Binders
Dustin Britton, Dia A. Ghose, Jackson C. Halpin, Foster Birnbaum, Kruthi Gundu, Shaunak Raval, Malvina Papanastasiou, Steven A. Carr, Amy E. Keating
This paper introduces seed-guided diffusion-based design to improve structural diversity and target contact in antitoxin protein binders, achieving functional binders with enhanced selectivity.
bioRxiv · Aug 4, 2026 · PreprintBioengineering