Malvina Papanastasiou

This paper introduces seed-guided diffusion-based design to improve structural diversity and target contact in antitoxin protein binders, achieving functional binders with enhanced selectivity.

The paper identifies SWIFT, a SWI/SNF subunit domain that mediates transcription factor interactions, showing its role in chromatin targeting and cancer cell proliferation.

This paper develops a mass spectrometry-based method to profile single-cell histone post-translational modifications, demonstrating its ability to detect treatment responses and chromatin heterogeneity.

This study identifies two mechanisms that rescue DNMT3A R882H activity by analyzing combinatorial mutations and showing R882H promotes aberrant oligomerization.

The paper identifies HDAC1/2 inhibition as a method to promote colorectal cancer differentiation through H3K27ac gains, which can be reversed by blocking EP300.

The paper presents a LINCS Microenvironment perturbation dataset cataloging transcriptional, proteomic, epigenomic, and phenotypic responses of MCF10A cells to six ligands, enabling integrative analysis of molecular and phenotypic changes.

The paper creates a proteomic resource profiling 90 drugs in six cell lines, revealing cell-specific responses and enabling integration with transcriptional data to identify therapeutic opportunities.