Foster Birnbaum

This paper introduces Proton-PottsMPNN, a model that designs pH-sensitive binders by explicitly modeling protonation states, resulting in pH-dependent PD-L1 binders with transition pH values between 4.0 and 5.8.

This paper introduces seed-guided diffusion-based design to improve structural diversity and target contact in antitoxin protein binders, achieving functional binders with enhanced selectivity.

This paper introduces PottsMPNN, a model trained to generate Potts energy functions for protein design, showing improved sequence generation and energy prediction over native sequence recovery.

This study develops CHANCLA, a multiomic platform to screen oncohistones, revealing their impact on chromatin and cell fate through functional and structural analyses.

The paper investigates two STAT5B mutations in T cell leukemias, showing one causes gain-of-function and the other loss-of-function, with distinct impacts on immune cell populations and transcriptional activity.