Jackson C. Halpin

The paper screens a proteome-wide peptide library to identify LC3B binding determinants, revealing exceptions to the canonical LIR motif and highlighting sequence features that influence binding affinity and specificity.

This paper introduces seed-guided diffusion-based design to improve structural diversity and target contact in antitoxin protein binders, achieving functional binders with enhanced selectivity.

PairK improves prediction of biologically relevant SLiM interactions by quantifying motif conservation in disordered regions more effectively than existing methods.