Mitochondrial fitness influences neuronal excitability of dopaminergic neurons from patients with idiopathic form of Parkinson's disease
Paula Chlebanowska, Agata Szlaga, Anna Tejchman, Marta Kot, Paweł S. Konieczny, Klaudia Skrzypek, Agata Muszyńska, Małgorzata Katarzyna Sobocińska, Krystyna Golebiowska, Paweł P. Łabaj, Anna Błasiak, Marcin Majka
The paper investigates mitochondrial dysfunction in iPSC-derived dopaminergic neurons from idiopathic Parkinson's disease patients, finding reduced mitochondrial fitness and ATP availability linked to decreased neuronal excitability.
bioRxiv · Apr 28, 2023 · PreprintNeuroscience