Lactate epigenetically shapes tumor cell states in H3K27M diffuse midline gliomas
Joanna Lum, Nicholas Nuechterlein, Shelby Sliger, Sanjana Eyunni, Benita Tamrazi, Stefan Blüml, Wentao Tian, Akash Deogharkar, Stefan R. Sweha, Mateus Mota, Jill M. Bayliss, Erik R. Peterson, Sunjong Ji, Molly Wittwer, Ksheetesha Bhat, , Sriram Venneti
This study shows lactate epigenetically regulates cell states in H3K27M diffuse midline gliomas by modifying histones, and targeting CBP/p300 reduces tumor heterogeneity and improves preclinical outcomes.
bioRxiv · Oct 6, 2026 · PreprintMolecular Biology