Author

Nicholas Nuechterlein

University of MichiganORCID 0000-0002-9599-0865Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Organism:human· 3 Approach:statistical model· 3 Research Focus:clustering· 2 Research Focus:database / resource· 2 Approach:machine learning (classical)· 1

Frequent Co-Authors

Eric C. HollandiD· 2 shared Matt JenseniD· 2 shared Sonali AroraiD· 2 shared Abhijit ParoliaiD· 1 shared Akash DeogharkariD· 1 shared Ana Azambuja· 1 shared Andrey KorshunoviD· 1 shared Arul M. ChinnaiyaniD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersBioinformatics

Eric C. HollandORCID

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Author profile →

3 papers

Recent·Most cited

Lactate epigenetically shapes tumor cell states in H3K27M diffuse midline gliomas

Joanna Lum, Nicholas Nuechterlein, Shelby Sliger, Sanjana Eyunni, Benita Tamrazi, Stefan Blüml, Wentao Tian, Akash Deogharkar, Stefan R. Sweha, Mateus Mota, Jill M. Bayliss, Erik R. Peterson, Sunjong Ji, Molly Wittwer, Ksheetesha Bhat, , Sriram Venneti

This study shows lactate epigenetically regulates cell states in H3K27M diffuse midline gliomas by modifying histones, and targeting CBP/p300 reduces tumor heterogeneity and improves preclinical outcomes.

bioRxiv · Oct 6, 2026 · PreprintMolecular Biology

Integrated transcriptomic landscape of medulloblastoma and ependymoma reveals novel tumor subtype-specific biology

Sonali Arora, Nicholas Nuechterlein, Matt Jensen, Gregory Glatzer, Philipp Sievers, Srinidhi Varadharajan, Andrey Korshunov, Felix Sahm, Stephen C. Mack, Michael D. Taylor, Taranjit S. Gujral, Eric C. Holland

The paper constructs a transcriptomic landscape for medulloblastoma and ependymoma, revealing subtype-specific biology through clustering and molecular signatures.

Neuro-Oncology · Oct 18, 2025Peer-reviewedBioinformatics

An RNA seq-based reference landscape of human normal and neoplastic brain

Sonali Arora, Frank Szulzewsky, Matt Jensen, Nicholas Nuechterlein, Siobhan S. Pattwell, Eric C. Holland

The paper combines five RNA-seq datasets to create a reference landscape of human brain tissues and tumors, enabling comparative gene expression analysis across normal and neoplastic samples.

bioRxiv · Jan 3, 2023 · PreprintBioinformatics