Resistance from Afar: Distal Mutation V36M Allosterically Modulates the Active Site to Accentuate Drug Resistance in HCV NS3/4A Protease
Ayşegül Özen, Kuan-Hung Lin, Keith P. Romano, Davide Tavella, Alicia Newton, Christos J. Petropoulos, Wei Huang, Cihan Aydın, Celia A. Schiffer
This study investigates how the distal mutation V36M confers drug resistance in HCV NS3/4A protease through allosteric modulation of the active site, in the context of R155K.
bioRxiv · Dec 16, 2018 · PreprintMolecular Biology