ImmunologybioRxivPreprint
Functional genomics identifies extension of complex N-glycans as a mechanism to evade lysis by natural killer cells
Xiaoxuan Zhuang, James Woods, Yanlong Ji…·Eric O. Long
The paper identifies SPPL3 as a gene that enables tumor cells to evade NK cell lysis by altering N-glycan structures, and shows that inhibiting N-glycan maturation restores NK sensitivity.
DOI 10.1101/2023.04.03.535404