Henning Urlaub

This study shows non-coding RNA disrupts enhancer-promoter interactions when increased, and stabilizes them when decreased, independent of transcription initiation.

The paper shows that phosphorylation of NOB1, an endoribonuclease, affects 18S rRNA processing and pre-rRNA levels during small subunit biogenesis.

The paper determines the cryo-EM structure of cytoplasmic Pol II and shows Gdown1 inhibits its transcriptional activity by blocking essential factor binding.

The paper identifies 3'UTR sequences that promote cap-independent translation initiation in human mRNAs, revealing a new regulatory mechanism involving translation factors.

The paper identifies RNA helicase partners of G-patch proteins and reveals distinct regulatory mechanisms by which they influence mRNA maturation.

This study demonstrates that AAV-mediated PRPF31 gene therapy restores splicing homeostasis and rescues RP11 phenotypes in patient-derived RPE and retinal organoids.

The paper shows that Loc1p and She2p undergo PUN motif-dependent liquid-liquid-phase separation, which is essential for early ASH1 mRNA transport.

The paper uses Alphafold3 to predict and validate the structure of the Imp{beta}/Imp7/H1 complex, showing H1 binds to Imp7 rather than Imp{beta} and identifying key interaction regions.

The paper develops a biocompatible fluorescent probe for tubulin labeling in live and fixed cells, enabling high-resolution imaging with minimal functional disruption.

The paper identifies a novel antibiotic resistance mechanism where fusA mutations slow ribosome movement when aminoglycosides are bound, preventing error cluster formation and maintaining bacterial growth.

This study reveals a three-step mechanism of co-transcriptional H3K36 methylation by SETD2 through cryo-EM structures and functional analysis.

This study identifies novel protein-protein interactions of PMP22 using optimized co-immunoprecipitation and mass spectrometry across multiple cell types.

The paper identifies Mos-MAPK targets in starfish oocytes using phosphoproteomics, revealing roles in mRNA polyadenylation and cytoskeletal regulation during meiosis.

This study identifies molecular signatures of aging in the mouse brain through proteo-transcriptomic analysis, revealing changes in protein aggregation, mRNA relocalization, and translation efficiency linked to neurodegeneration.

The paper introduces chemical crosslinking with mass spectrometry and a new search engine, NuXL, to identify nucleic acid-protein crosslinks at amino acid resolution, enhancing structural analysis.

This study investigates how ULK1 activity influences ATG101 auto-activation dynamics, revealing a memory mechanism that accelerates autophagy complex formation.

The paper profiles the LAM family of contact site tethers to understand their localization and function, revealing unique and shared roles through proximity labeling.

The paper introduces NbLumSyt1 nanobinders for analyzing synaptic vesicle dynamics in rodent and human models with improved precision and versatility.

This study presents cryo-EM structures of Nipah virus RdRp in apo and early elongation states, revealing its architecture and RNA interaction mechanisms.

This study shows that Plk1 inhibition delays mitotic entry, revealing prophase-specific phosphoproteome changes and highlighting Plk1's role in the prophase to prometaphase transition.

The paper identifies Cas11b as an internally translated protein in an archaeal CRISPR-Cas system, showing its necessity for effective interference and Cascade complex formation.

This study identifies the molecular interactions of UPF1 in histone mRNA decay, showing how SLBP and UPF2 regulate its unwinding activity and degradation efficiency.

This study determines the cryo-EM structures of human myoferlin and dysferlin bound to Ca2+ and lipids, revealing how their domain dynamics enable membrane binding and fusion.

The paper reports cryo-EM structures of aberrant spliceosome intermediates in S. pombe, revealing how a helicase-protein pair maintains catalytic dormancy and facilitates disassembly.

The paper deletes four proviruses in Haloferax volcanii and finds increased motility, stress resistance, and altered CRISPR RNA expression.

This study identifies a DNA binding region in MORC2 that is essential for gene silencing and shows that phosphorylation affects its DNA affinity and nuclear localization.

The paper introduces mCP, a streamlined workflow for detecting protein complexes with reduced fractionation, and demonstrates its application in analyzing cardiac tissue.

This study introduces PulsPhos, a method to quantify site-specific phosphorylation lifetimes in living cells and applies it to pharmacological perturbations.

The paper identifies calcium-dependent ubiquitination events in synapses, showing that ubiquitination of CaMKII and AP180 modulates synaptic function through autophosphorylation.