Neuroprotective derivatives of tacrine that target NMDA receptor and acetyl cholinesterase - Design, synthesis and biological evaluation
Chandran Remya, Kalarickal Vijayan Dileep, Eeda Koti Reddy, Kumar Mantosh, Lakshmi Kesavan, Reena Sarah Jacob, Ayyiliath Meleveetil Sajith, E. Jayadevi Variyar, Shaik Anwar, Kam Y. J. Zhang, Chittalakkottu Sadasivan, R.V. Omkumar
The paper designs, synthesizes, and evaluates neuroprotective derivatives of tacrine that target both acetylcholinesterase and NMDA receptors, showing reduced hepatotoxicity and potential therapeutic benefits.
Computational and Structural Biotechnology Journal · Jan 1, 2021Peer-reviewedNeuroscience