Author

Chittalakkottu Sadasivan

Kannur UniversityORCID 0000-0002-9685-6676Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:rat· 1

Frequent Co-Authors

Amrutha Nisthul A.· 1 shared Archana Praveen· 1 shared Arun (Geetha) ViswanathaniD· 1 shared Ayyiliath Meleveetil SajithiD· 1 shared Chandran RemyaiD· 1 shared Chenicheri Kizhakkeveettil KeerthanaiD· 1 shared E. Jayadevi VariyariD· 1 shared Eeda Koti ReddyiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperCancer Biology

Amrutha Nisthul A.

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Uttroside B, a US FDA-designated Orphan drug, mitigates thedevelopment of hepatocellular carcinoma and its pulmonary metastasis via EGFR/ERK-mediated inhibition of SREBP-1 and STAT-3

Chenicheri Kizhakkeveettil Keerthana, Tennyson Prakash Rayginia, Kalimuthu Kalishwaralal, Sandhini Saha, Nair Hariprasad Haritha, Amrutha Nisthul A., Mundanattu Swetha, Sreekumar Usha Devi Aiswarya, Lekshmi R. Nath, Sanjay Suresh Varma, Arun (Geetha) Viswanathan, Somaraj Jannet, Shirly J, Jayasekharan S. Aparna, Archana Praveen, , Ruby John Anto

This study shows that Uttroside B inhibits hepatocellular carcinoma and its pulmonary metastasis by blocking the EGFR/ERK pathway and its downstream targets SREBP-1 and STAT-3.

Cell Death Discovery · Apr 16, 2026Peer-reviewedCancer Biology

Neuroprotective derivatives of tacrine that target NMDA receptor and acetyl cholinesterase - Design, synthesis and biological evaluation

Chandran Remya, Kalarickal Vijayan Dileep, Eeda Koti Reddy, Kumar Mantosh, Lakshmi Kesavan, Reena Sarah Jacob, Ayyiliath Meleveetil Sajith, E. Jayadevi Variyar, Shaik Anwar, Kam Y. J. Zhang, Chittalakkottu Sadasivan, R.V. Omkumar

The paper designs, synthesizes, and evaluates neuroprotective derivatives of tacrine that target both acetylcholinesterase and NMDA receptors, showing reduced hepatotoxicity and potential therapeutic benefits.

Computational and Structural Biotechnology Journal · Jan 1, 2021Peer-reviewedNeuroscience