Reversal of drug resistance by disruption of a Gain-of-Function mutant p53 and transcriptional co-activator PC4 interaction
Priya Mondal, Kumar Singha Roy, Tapas Kumar Kundu, Susanta Roychoudhury, Siddhartha Roy
This study shows that disrupting the interaction between PC4 and the gain-of-function p53 mutant R273H reduces drug resistance by lowering MDR1 expression.
bioRxiv · Feb 17, 2023 · PreprintMolecular Biology