Siddhartha Roy

This paper develops a liposome-peptide formulation that enhances doxorubicin's effectiveness against p53R273H mutant tumors by disrupting PC4 interaction.

This study investigates how the lac repressor protein interacts with two different DNA operators through structural and dynamic changes using molecular modeling and simulations.

This study shows that disrupting the interaction between PC4 and the gain-of-function p53 mutant R273H reduces drug resistance by lowering MDR1 expression.

This study shows that p53 enhances p300 autoacetylation through structural changes, which is critical for gene regulation and may be targeted to treat tumors.