Tapas Kumar Kundu

This study shows that elevated Mcm7 levels disrupt microtubule and nucleolar homeostasis, leading to genome instability and cell death in yeast, with implications for human cancer.

This study shows that KAT5 acetylates PC4 at K80 to enhance DNA repair, and this acetylation is critical for DNA damage response.

This study identifies T13F2.2 as a critical gene in C. elegans that affects chromatin structure, autophagy, and lifespan through RNAi depletion and transcriptomic analysis.

This study identifies HIV-1C LTR variants that influence latency and reservoir stability, showing R2 strains resist reversal and contribute to persistent reservoirs.

This study shows that modulating histone acetylation with a small molecule activator improves synaptic and behavioural deficits in a SYNGAP1 mutation model.

This study identifies TFIIIC220 as a lysine acetyltransferase that acetylates histone H3K18, highlighting its role in maintaining acetylation homeostasis.

This study shows oral administration of CSP-TTK21 achieves synaptic plasticity and spinal cord injury repair effects similar to intraperitoneal delivery in mice and rats.

This study shows that disrupting the interaction between PC4 and the gain-of-function p53 mutant R273H reduces drug resistance by lowering MDR1 expression.

This study shows that p300-mediated histone butyrylation is essential for adipogenesis and obesity, with a specific inhibitor reducing adipocyte growth and weight gain in mouse models.

The paper analyzes SARS-CoV-2 genome variations across different COVID-19 patient subgroups to identify associations with disease severity and outcomes.

This study shows that PC4 maintains genomic integrity by regulating chromatin structure and autophagy, with its loss increasing radiation resistance through autophagy enhancement.

This study shows that acetylation of catalytic lysine in CDK1 regulates Cyclin-B binding, with SIRT1 and P300 opposing this modification, and that acetylation mimics in yeast block cell cycle progression.

This study shows that p53 enhances p300 autoacetylation through structural changes, which is critical for gene regulation and may be targeted to treat tumors.