Tobacco Carcinogen Induces Persistent DNA Damage and Homologous Recombination Dysregulation in Pancreatic Ductal Carcinogenesis
Varunkumar Krishnamoorthy, Vineet Kumar Gupta, Sudhakar Jinka, Supriya Srinivasan, Kumaraswamy H M, Chanjuan Shi, Poorva Poorva, Steven Xi Chen, Nipun B. Merchant, Austin R. Dosch, Nagaraj S. Nagathihalli
This study shows that NNK induces acute DNA damage and chronic HR repair dysregulation in pancreatic cells, linked to genomic instability and poor prognosis in PDAC.
bioRxiv · Oct 15, 2026 · PreprintCancer Biology