Author

Nagaraj S. Nagathihalli

University of MiamiORCID 0000-0003-2373-3293Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Nipun B. MerchantiD· 3 shared Anna BianchiiD· 2 shared Austin R. DoschiD· 2 shared Haleh AmirianiD· 2 shared Jashodeep DattaiD· 2 shared Karthik RajkumariD· 2 shared Siddharth MehraiD· 2 shared Sudhakar JinkaiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersCancer Biology

Nipun B. MerchantORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintOct 15, 2026

Tobacco Carcinogen Induces Persistent DNA Damage and Homologous Recombination Dysregulation in Pancreatic Ductal Carcinogenesis

Varunkumar Krishnamoorthy, Vineet Kumar Gupta, Sudhakar Jinka…·Nagaraj S. Nagathihalli

This study shows that NNK induces acute DNA damage and chronic HR repair dysregulation in pancreatic cells, linked to genomic instability and poor prognosis in PDAC.

DOI 10.64898/2026.10.13.758888

humanbulk RNA-seq

𝕏 PostBluesky

Cancer BiologybioRxivPreprintDec 8, 2025

Targeting CREB remodels the immune microenvironment to enhance immunotherapy responses in pancreatic cancer

Siddharth Mehra, Supriya Srinivasan, Sudhakar Jinka…·Nagaraj S. Nagathihalli

This study shows that targeting CREB reduces immunosuppression in pancreatic cancer by altering macrophage polarization and enhancing immunotherapy effectiveness.

DOI 10.64898/2025.12.04.691935

mousebulk RNA-seq

𝕏 PostBluesky

Cancer BiologyCancer Immunology ImmunotherapyPeer-reviewedJun 23, 2025

Cell-specific nanoengineering strategy disrupts tolerogenic signaling from myeloid-derived suppressor cells to invigorate antitumor immunity in pancreatic cancer

Nilesh Deshpande, Anna Bianchi, Haleh Amirian…·Jashodeep Datta

The paper develops CXCR2-homing nanoparticles to specifically target PMN-MDSCs in PDAC, reducing arginase activity and enhancing T-cell activity without causing neutropenia.

10 citations

mouseexperimental assay

𝕏 PostBluesky