Nipun B. Merchant

Tobacco Carcinogen Induces Persistent DNA Damage and Homologous Recombination Dysregulation in Pancreatic Ductal Carcinogenesis

This study shows that NNK induces acute DNA damage and chronic HR repair dysregulation in pancreatic cells, linked to genomic instability and poor prognosis in PDAC.

Targeting CREB remodels the immune microenvironment to enhance immunotherapy responses in pancreatic cancer

This study shows that targeting CREB reduces immunosuppression in pancreatic cancer by altering macrophage polarization and enhancing immunotherapy effectiveness.

Knowledge-informed multimodal cfDNA analysis improves sensitivity and generalization in cancer detection

Fate-AI improves cancer detection sensitivity and generalization by integrating fragmentomic and methylation features from cfDNA sequencing.

Cell-specific nanoengineering strategy disrupts tolerogenic signaling from myeloid-derived suppressor cells to invigorate antitumor immunity in pancreatic cancer

The paper develops CXCR2-homing nanoparticles to specifically target PMN-MDSCs in PDAC, reducing arginase activity and enhancing T-cell activity without causing neutropenia.

Multi-omic characterization reveals a distinct molecular landscape in young-onset pancreatic cancer

This study compares molecular features of young-onset and average-onset pancreatic cancer using multi-omic data, finding distinct mutation patterns and immune profiles with prognostic implications.