Author

Vineet Kumar Gupta

University of MiamiORCID 0000-0002-0307-9485Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Austin R. DoschiD· 2 shared Nagaraj S. NagathihalliiD· 2 shared Nipun B. MerchantiD· 2 shared Sudhakar JinkaiD· 2 shared Supriya SrinivasaniD· 2 shared Varunkumar KrishnamoorthyiD· 2 shared Andrew Mark AdamsiD· 1 shared Anna BianchiiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersCancer Biology

Austin R. DoschORCID

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2 papers

Recent·Most cited

Tobacco Carcinogen Induces Persistent DNA Damage and Homologous Recombination Dysregulation in Pancreatic Ductal Carcinogenesis

Varunkumar Krishnamoorthy, Vineet Kumar Gupta, Sudhakar Jinka, Supriya Srinivasan, Kumaraswamy H M, Chanjuan Shi, Poorva Poorva, Steven Xi Chen, Nipun B. Merchant, Austin R. Dosch, Nagaraj S. Nagathihalli

This study shows that NNK induces acute DNA damage and chronic HR repair dysregulation in pancreatic cells, linked to genomic instability and poor prognosis in PDAC.

bioRxiv · Oct 15, 2026 · PreprintCancer Biology

Targeting CREB remodels the immune microenvironment to enhance immunotherapy responses in pancreatic cancer

Siddharth Mehra, Supriya Srinivasan, Sudhakar Jinka, Varunkumar Krishnamoorthy, Vineet Kumar Gupta, Vanessa T. Garrido, Anna Bianchi, Andrew Mark Adams, Manan S. Patel, Haleh Amirian, Luis Alberto Nivelo, Karthik Rajkumar, Rimpi Khurana, Edmond W. Box, Yuguang J. Ban, , Nagaraj S. Nagathihalli

This study shows that targeting CREB reduces immunosuppression in pancreatic cancer by altering macrophage polarization and enhancing immunotherapy effectiveness.

bioRxiv · Dec 8, 2025 · PreprintCancer Biology