Functional disruption of vgsc reveals haplosufficiency with implications for insecticide resistance and genetic control in Anopheles gambiae
Poppy Pescod, Ashley Hall, Sian Yates-Wakley, Matthew W. Craske, Louise Marston, Amalia Anthousi, Carla Siniscalchi, Josephine Shepherd, Molly Kelly, Saffron Mackey, Kurtis Blinkhorn, Tony Nolan
This study generates CRISPR-edited Anopheles gambiae lines to investigate vgsc's role in insecticide resistance and genetic control, finding haplosufficiency and reduced susceptibility to pyrethroids.
bioRxiv · Sep 11, 2026 · PreprintGenetics