Tony Nolan

This study generates CRISPR-edited Anopheles gambiae lines to investigate vgsc's role in insecticide resistance and genetic control, finding haplosufficiency and reduced susceptibility to pyrethroids.

This study shows Rdl resistance mutations in mosquitoes enhance auditory function and mating success, contributing to their persistence in urban environments.

The paper investigates repair outcomes after I-SceI cleavage in Anopheles gambiae, showing homology-based repair dominates and can generate meiotic drive-like distortion.

This paper develops a targeted genomic surveillance approach for insecticide resistance in malaria vectors, identifying resistance variants and demonstrating predictive modeling with high accuracy.

The paper introduces a Y chromosome-linked genome editor (YLE) for population suppression in Anopheles gambiae, showing it is up to 8 times more efficient than other self-limiting strategies.

The paper presents a pipeline to discover and engineer gene drives that overcome resistance in malaria mosquitoes, showing that new resistant alleles can emerge and designing drives that target multiple sites to suppress populations.

This study evaluates how genetic variation and chromosomal inversions affect CRISPR-Cas9 gene drive homing in Anopheles gambiae strains, finding no significant reduction in homing despite target site heterogeneity.

The paper evaluates resistance to a CRISPR-based gene drive by simulating high selection pressure in Anopheles gambiae and identifies a resistant mutation at an ultra-conserved site.

This study functionally validates the L1014F kdr mutation's role in pyrethroid resistance in Anopheles gambiae and shows its interaction with detoxification enzymes.

This paper describes an optimized CRISPR-based system for transgene insertion in Anopheles funestus, enabling efficient homology-directed repair for genetic modifications.

The paper identifies ultra-conserved sequences in Anopheles mosquito genomes and suggests their potential use as targets for gene drive-based malaria control.

The paper develops an integrated resource to analyze small RNA profiles in mosquitoes, revealing evolutionary dynamics and host responses to viruses and transposons.

This study improves gene drive efficacy by reducing resistance and fitness costs through regulatory sequence modifications, leading to better population suppression and delayed resistance.

The paper investigates the evolutionary dynamics of sex-biased genes in four Anopheles mosquito species, finding female-biased genes evolve faster than male-biased ones due to sex-specific challenges.

The paper demonstrates that Y chromosomes from two malaria vector species in the Anopheles gambiae complex function interchangeably, suggesting no hybrid incompatibility loci on the Y and enabling potential cross-species sex-distorting Y drive interventions.