Astrocytic TIMP-1 regulates production of Anastellin, a novel inhibitor of oligodendrocyte differentiation and FTY720 responses
Pearl A. Sutter, Cory M. Willis, Antoine Ménoret, Alexandra M. Nicaise, Anthony V. Sacino, Arend H. Sikkema, Evan R. Jellison, Kyaw K. Win, David K. M. Han, William H. Church, Wia Baron, Anthony T. Vella, Stephen J. Crocker
This study identifies anastellin, a fibronectin-derived peptide produced by astrocytes lacking TIMP-1, which inhibits oligodendrocyte differentiation and reduces FTY720 efficacy in multiple sclerosis.
bioRxiv · Feb 17, 2023 · PreprintNeuroscience