Cory M. Willis

This study identifies increased cholesterol synthesis in PMS patient-derived neural progenitor cells as a driver of neurotoxicity, which can be mitigated by simvastatin.

This study identifies dark microglia in postnatal mouse hippocampus, showing they perform synapse remodeling via phagocytosis and trogocytosis and depend on TREM2.

This study identifies anastellin, a fibronectin-derived peptide produced by astrocytes lacking TIMP-1, which inhibits oligodendrocyte differentiation and reduces FTY720 efficacy in multiple sclerosis.

This study identifies synapse loss and microglial synaptic engulfment in MS models and demonstrates that targeted complement inhibition prevents synapse loss and visual dysfunction.