Anthony T. Vella

This paper shows that endothelial cells suppress CD8 T cell responses in atherosclerosis via Elavl1-regulated translational control of immune-regulatory proteins.

This study identifies PTBP1 as a key regulator of endothelial dysfunction in cardiac allograft vasculopathy, showing its deletion reduces fibrosis and immune activation in mouse models.

This study identifies UBXN1's role in activating the non-canonical inflammasome via unanchored ubiquitin chains, showing its importance in sepsis and inflammasome signaling.

This study identifies anastellin, a fibronectin-derived peptide produced by astrocytes lacking TIMP-1, which inhibits oligodendrocyte differentiation and reduces FTY720 efficacy in multiple sclerosis.

This study shows that CD8+ T-cell depletion prevents myelin pathology in a mouse model of Globoid Cell Leukodystrophy.

This review discusses mathematical and computational models addressing challenges in cancer immunotherapy, including tumor classification, treatment scheduling, and combination therapy design.