Alexandra M. Nicaise

The paper introduces Flufftail, a framework for fuzzy clustering in single-cell data, to infer gene regulatory network dynamics by leveraging membership probabilities and regulatory hub genes.

This study identifies increased cholesterol synthesis in PMS patient-derived neural progenitor cells as a driver of neurotoxicity, which can be mitigated by simvastatin.

The paper identifies mitochondrial reverse electron transport in myeloid cells as a driver of neuroinflammation and shows that blocking it protects the CNS in disease models.

This study identifies anastellin, a fibronectin-derived peptide produced by astrocytes lacking TIMP-1, which inhibits oligodendrocyte differentiation and reduces FTY720 efficacy in multiple sclerosis.

This study shows that CD8+ T-cell depletion prevents myelin pathology in a mouse model of Globoid Cell Leukodystrophy.