Genetic suppression of myeloid receptor Clec7a attenuates microglia neuroinflammation and promotes microglial phagocytosis to delay disease progression in ALS models
Xuan Chen, Huilan Yan, Haichao Wei, Sanaz Sajadi, Jingwen Hu, Vinicius Matos Vasconcellos, Ashley Kim, Tarun Shriram, Huizhong Tan, Kyoeun Keum, Jiaqian Wu, Martin Paukert, Yongjie Yang
This study shows that reducing Clec7a in microglia reduces neuroinflammation and improves phagocytosis, slowing ALS progression in mouse models.
bioRxiv · May 7, 2026 · PreprintNeuroscience