Xuan Chen

This study combines spatial transcriptomics and snRNA-seq to map cell type organization and functional modules in the mouse amygdala, revealing developmental origins and spatial patterns.

The paper creates a spatiotemporal transcriptome atlas of human embryos after gastrulation, revealing organ-specific regulons and regulatory networks during development.

This study shows that reducing Clec7a in microglia reduces neuroinflammation and improves phagocytosis, slowing ALS progression in mouse models.

This study shows that paternal chronic social instability stress reduces sperm miR-34c levels via astrocyte-derived exosomes, which are transmitted to offspring and contribute to transgenerational stress-related traits.

This study identifies cellular and molecular differences in RRDCD compared to RRD, highlighting microglia and complement C5/C5a pathway involvement in inflammation and blood-retina barrier dysfunction.

This study identifies an astroglial exosome pathway that promotes axon growth and dendritic spine formation in cortical pyramidal neurons, with ApoE inhibiting this effect.