A self-limiting orexin-habenula circuit for stress resilience
Soo Hyun Yang, Esther Yang, Jin Taek Jung, Jaekwang Lee, Gyeong Hee Pyeon, Yong Sang Jo, Hyung Sun Park, J I Moon, Jae‐Yong Park, Kyung-Jun Boo, Dongmin Lee, Sungkun Chun, Hyeijung Yoo, Hyun Woo Lee, Hyun Kim
This paper identifies a self-limiting orexin-habenula circuit that promotes stress resilience by modulating dopamine and coping behaviors, and shows that chronic stress disrupts this circuit through epigenetic and inflammatory mechanisms.
bioRxiv · May 9, 2026 · PreprintNeuroscience